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Different binding of propranolol enantiomers to human alpha1-acid glycoprotein

✍ Scribed by Jana Oravcová; Slavomír Bystricky; Tomáš Trnovec


Book ID
115781170
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
503 KB
Volume
38
Category
Article
ISSN
0006-2952

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Enantioselective binding of propranolol,
✍ Kazuhiko Hanada; Toshikuni Ohta; Masahiko Hirai; Miki Arai; Hiroyasu Ogata 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 201 KB

We investigated the binding of propranolol (PL), disopyramide (DP), and verapamil (VP) enantiomers by human alpha(1)-acid glycoprotein (AGP; also called orosomucoid) and the relationships between the extent of drug binding and lipophilicity, desialylation, and genetic variants of AGP. Desialylation