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Different aetiologies of Type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects

โœ Scribed by P. Arner; T. Pollare; H. Lithell

Publisher
Springer
Year
1991
Tongue
English
Weight
506 KB
Volume
34
Category
Article
ISSN
0012-186X

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โœฆ Synopsis

Insulin responses to intravenous glucose infusion and glucose utilization during hyperinsulinaemic euglycaemic clamp were determined in a large homogeneous group of 65-year-old male subjects. Twenty-eight had untreated Type 2 (non-insulin-dependent) diabetes mellitus and the remaining 44 control subjects had a normal glucose tolerance. Diabetic patients with abdominal obesity displayed peripheral insulin resistance in combination with de-fective insulin secretion, whereas non-obese diabetic patients showed only a secretory defect. Thus, Type 2 diabetes in obese and non-obese elderly male subjects may take two forms where the cause of hyperglycaemia differs.

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