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Differences in the protein-kinase-A-dependent regulation of CFTR Cl–channels and Na+–K+pumps in guinea-pig ventricular myocytes

✍ Scribed by Jens Kockskämper; Kirsty Sendhoff; Simone Erlenkamp; Frank Bordusa; Vaclav Cerovsky; Helfried G. Glitsch

Publisher
Springer
Year
2001
Tongue
English
Weight
107 KB
Volume
441
Category
Article
ISSN
0031-6768

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The catalytic subunit of cyclic AMP-depe
The catalytic subunit of cyclic AMP-dependent protein kinase directly inhibits sodium channel activities in guinea-pig ventricular myocytes
✍ A. Sunami; Z. Fan; F. Nakamura; M. Naka; T. Tanaka; T. Sawanobori; M. Hiraoka 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 288 KB

We investigated the effects of the purified catalytic subunit (C subunit) of the cAMP-dependent protein kinase (A-kinase) on the cardiac Na+ channel currents. Single Na+ channel currents in guinea-pig ventricular myocytes were recorded using the patch clamp technique of the inside-out configuration.