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Differences in the properties of Na+channels in muscle surface and T-tubular membranes revealed by tetrodotoxin derivatives

โœ Scribed by E. Jaimovich; R. Chicheportiche; A. Lombet; M. Lazdunski; M. Ildefonse; O. Rougier


Publisher
Springer
Year
1983
Tongue
English
Weight
569 KB
Volume
397
Category
Article
ISSN
0031-6768

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We previously characterized two monoclonal antibodies, A/B2 and L/D3, that bind to the amino-terminus of the sodium channel but produce distinct immunocytochemical patterns in innervated adult skeletal muscle. Because these findings suggested the presence of several channel isoforms, we sought to de