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Differences in the kinetic properties of thymidine kinase isoenzymes in unstimulated and phytohemagglutinin-stimulated human lymphocytes

✍ Scribed by Birgitte Munch-Petersen


Publisher
Springer
Year
1984
Tongue
English
Weight
779 KB
Volume
64
Category
Article
ISSN
0300-8177

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The inhibitors of DNA synthesis, 5-fluoro-2'-deoxyuridine and hydroxyurea, caused an inhibition of thymidine kinase, replicative DNA polymerase and CDP reductase activities in stimulated lymphocytes when they were exposed to the inhibitors during the early transformation period (0-17 hr). However, t