Differences in the induction of cytochrome P450 3A4 by taxane anticancer drugs, docetaxel and paclitaxel, assessed employing primary human hepatocytes

Effect of silybin and its glycosides on

Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes

✍ Pavel Kosina; Patrick Maurel; Jitka Ulrichová; Zdeněk Dvořák 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB 👁 1 views

## Abstract Four β‐glycosides of flavonoligan silybin, i.e. silybin β‐galactoside, silybin β‐glucoside, silybin β‐maltoside, silybin β‐lactoside were synthesized in order to improve silybin water solubility and bioavailability (Křen et al., J Chem Soc, Perkin Trans 1, 2467–2474, 1997). The presente