Differences in the immunological activities of antibody-secreting cell precursors in mouse spleen selected on the basis of antigen-binding capacity

✍ Scribed by L. Lafleur; G. F. Mitchell

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 451 KB
• Volume: 5
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830050913

✦ Synopsis

Abstract

Mouse spleen cells transfer a retarded and lower than normal IgG antibody response after removal of cells with a high antigen‐binding capacity. The population enriched in these latter cells transfers a response equal to or, more often, higher than the response of the unfractionated controls and does not appear to have originated from previous priming of the mice. These cells are present in athymic nude mice and appear to be more susceptible to inactivation by an anti‐Ig antiserum and complement than precursors of IgM antibody‐secreting cells.