Differences in the conformational behaviour of the potent and selective, Tyr-D.Thr-Gly-Phe-Leu-Thr(OtBu) and of the inactive Tyr-D.Thr(OtBu)-Gly-Phe-Leu-Thr δ-opioid ligands evidenced by 1H NMR
✍ Scribed by J. Belleney; G. Gacel; B. Maigret; M.C. Fournié-Zaluski; B.P. Roques
- Book ID
- 104203722
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 557 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4020
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## 3 In a previous work, the synthesis of [ HI Tyr-D-Thr-Gly-Phe-Leu-Thr (DTLET), a highly selective probe for 6 opioid receptors has been described. More recently, Az-DTLET (Tyr-D-Thr-Cly-Phe (pN 1-Leu-Thr) has been shown to be a specific and irreversible photoaffinity ligand for 6 opioid sites.
## Abstract The introduction of bulky residue (s) in linear enkephalin‐related hexapeptides represents a new approach in the design of selective probes for δ‐opioid receptors, displaying the appropriate criteria to investigate biological and pharmacological properties of the assumed binding site (δ