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Differences in rate of hydrolysis of HMG-CoA reductase inhibitors in human and animal tissues

โœ Scribed by Fukuo, Y.; Akaishi, H.; Honda, H.; Nagashima, M.; Muramatsu, T.; Terashi, A.; Yamada, Y.; Otuka, S.


Book ID
123590572
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
148 KB
Volume
109
Category
Article
ISSN
0021-9150

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## Abstract The cholesterolโ€lowering drug simvastatin (SIMV, Zocor^ยฎ^) reduced heart attacks by 42% in patients who had high cholesterol levels and suffered from heart disease. Upon oral administration, SIMV is quickly hydrolyzed to its ฮฒโ€hydroxyacid and other acid metabolites, which are potent inh