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Differences in Paclitaxel and Docetaxel Interactions with Tubulin Detected by Mutagenesis of Yeast Tubulin

✍ Scribed by Robert D. Winefield; Ruth A. Entwistle; Travis B. Foland; Gerald H. Lushington; Richard H. Himes

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
422 KB
Volume
3
Category
Article
ISSN
1860-7179

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Docetaxel (DOC), a member of the taxane family of anticancer drugs, binds to tubulin and produces unnaturally stable microtubules that induce cell death. DOC is used clinically alone or in combination with other compounds to treat advanced stages of cancer. We have treated the human lung cancer cell