✦ LIBER ✦
Differences in inhibition by IDF45 (an inhibitory diffusible factor) of early RNA synthesis stimulation induced by pp60 v-src and various mitogens
✍ Scribed by J. Delbe; J. Villaudy; C. Blat; G. Desauty; A. Golde; L. Harel
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 612 KB
- Volume
- 142
- Category
- Article
- ISSN
- 0021-9541
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✦ Synopsis
Factors inhibiting cell growth have been isolated from different cell types. However, little information is available concerning their mode of action. A novel growth inhibitory factor of 45 kDa (IDF,,) was recently purified to homogeneity from medium conditioned by 3T3 cells. 1-his molecule was able to inhibit DNA synthesis and the growth of chick embryo fibroblasts (CEF) in a reversible manner.