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Differences in FOXP3 and CD127 expression in Treg-like cells in patients with IPEX syndrome

✍ Scribed by Boldt, A.; Kentouche, K.; Fricke, S.; Borte, S.; Kahlenberg, F.; Sack, U.


Book ID
124109635
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
440 KB
Volume
153
Category
Article
ISSN
1090-2341

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Mutations of forkhead box p3 (__FOXP3__), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The rel