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Differences in anti-Fab antibodies in adult and late onset rheumatoid arthritis

✍ Scribed by F. Gamerith; G. J. Zlabinger; O. Scherak; G. Kolarz; M. Schemper; H. Heinzl; J. E. Menzel

Publisher
Springer
Year
1993
Tongue
English
Weight
570 KB
Volume
13
Category
Article
ISSN
0172-8172

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## Abstract Anti‐Fab antibody titers were positive in 70% of rheumatoid arthritis patients (54 of 77) and 3% (1 of 35) of healthy donors. Their specificity was examined by inhibition of the radioimmunoassay for anti‐Fab antibodies, which demonstrated that they are against the Fd region of the intac

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IgG4 comprises a significant proportion of the total anti-Fab antibody (aFABA) response in many but not all patients with rheumatoid arthritis (RA). Analyses of the dynamics of IgG aFABA subclass expression in 11 RA patients for periods of up to 11 months demonstrated that IgG4 aFABA was restricted