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Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations

โœ Scribed by Jean Bendaly; Mark A. Doll; Lori M. Millner; Kristin J. Metry; Ned B. Smith; William M. Pierce Jr.; David W. Hein


Book ID
113809356
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
616 KB
Volume
671
Category
Article
ISSN
0027-5107

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## Abstract Heterocyclic amine carcinogens such as 2โ€aminoโ€1โ€methylโ€6โ€phenylimidazo [4,5โ€b] pyridine (PhIP) are present in diet and cigarette smoke. Bioactivation in humans includes Nโ€hydroxylation catalyzed by cytochrome P4501A2 possibly followed by Oโ€acetylation catalyzed by Nโ€acetyltransferase 2