Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations
โ Scribed by Jean Bendaly; Mark A. Doll; Lori M. Millner; Kristin J. Metry; Ned B. Smith; William M. Pierce Jr.; David W. Hein
- Book ID
- 113809356
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 616 KB
- Volume
- 671
- Category
- Article
- ISSN
- 0027-5107
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Primary cultures of rat mammary epithelium and the human mammary cell line MCF-12 were incubated with 10 ยตM N-formyl-, N-acetyl-, or N-propionyl-derivatives of N-hydroxy-2-aminofluorene (N-OH-AF) or N-formyl-, or N-acetyl derivatives of Nhydroxy-4-aminobiphenyl (N-OH-ABP), in the medium with or with
## Abstract Heterocyclic amine carcinogens such as 2โaminoโ1โmethylโ6โphenylimidazo [4,5โb] pyridine (PhIP) are present in diet and cigarette smoke. Bioactivation in humans includes Nโhydroxylation catalyzed by cytochrome P4501A2 possibly followed by Oโacetylation catalyzed by Nโacetyltransferase 2