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Difference in Signal Transduction for IL-10 and IFN-γ Production in a CD8+T Cell Clone

✍ Scribed by Yuji Minai; Masao Goto; Masako Kohyama; Tatsuhiro Hisatsune; Ken-ichi Nishijima; Shuichi Kaminogawa


Book ID
112239632
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
103 KB
Volume
172
Category
Article
ISSN
0008-8749

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Phytohemagglutinin (PHA)-derived T lymphoblasts or T cell clones from patients genetically deficient in IL-12R g 1 (IL-12R g 1 -/-) or IFN-+ R1 (IFN-+ R1 -/-) produced two-to threefold reduced IFN-+ levels compared to the corresponding cells from healthy individuals after anti-CD3 and PMA stimulatio