Diethyl Fluoronitromethylphosphonate: Synthesis and Application in Nucleophilic Fluoroalkyl Additions
✍ Scribed by Opekar, Stanislav; Pohl, Radek; Beran, Pavel; Rulíšek, Lubomír; Beier, Petr
- Book ID
- 121814372
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 435 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0947-6539
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## Abstract A method for the preparation of 3‐(fluoroalkyl)‐substituted 2‐azabutadienes **5** by aza‐Wittig reaction of __N__‐vinylic 3‐(fluoroalkyl)phosphazenes **4** and aldehydes is reported. Thermal 6π‐electrocyclization of these azadienes gives 3‐(fluoroalkyl)‐substituted isoquinolines **6**.
After A Historical Introduction, All Synthetically Relevant Reaction Types Are Thoroughly Discussed, Followed By A Consideration Of Large Scale Applications. Additionally, The Most Frequently Used Organocatalysts Are Summarized In An Appendix, Aiding The Research Chemist In Selecting An Appropriate