Dietary supplementation with ω-3 polyunsaturated fatty acids from fish oil in chronic liver disease
✍ Scribed by J. J. Visser; S. Meijer; Kentaro Yoshiko; Donald Cohen; Crig J McCleain
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 353 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
Perfusion pressure (mm Hg)
Blood flow (L,min) 8o
Resistance (dyn . sec . cm6) = Thus, until a final apreement is achieved. we will have to multiply by 80 t; convert data reported as mm H&/min to dynsec cm6. Fortunately, this is not complicated.
As clearly stated in the paper, our results were obtained in patients with end-to-side portacaval shunts. These were chosen to circumvent difficulties inherent in the measurement of hepatic artery blood flow in humans. In these patients the liver is only perfused through the hepatic artery; therefore, measurement of total hepatic blood flow represents a measurement of hepatic artery blood flow. However, it is also true that the relationship between the portal vein and hepatic artery is lost under these conditions. As discussed in our paper, hepatic arterial resistance decreases when portal blood flow is diverted (3,4). It is likely, therefore, that in our patients the hepatic arterioles were already nearly maximally dilated. However, our findings indicate that hepatic artery blood flow actually decreased after nonselective p-blockade with propranolol. This is in accordance with observations made by Richardson and Withrington (5). Nevertheless, the study provided evidence on the maintenance of compensatory autoregulation of hepatic artery blood flow despite marked changes in cardiac output. However, this was not enough to prevent a fall in hepatic artery blood flow after propranolol administration (1). Do these findings have clinical implications in propranolol therapy in patients with cirrhosis? Since submission of this article, other studies have shown that propranolol administration may reduce hepatic blood flow in patients with cirrhosis (6)-which was not thought to occur in previous studies (2, 7). It is likely