Dietary regulation of 3-hydroxy-3-methylglutaryl-CoA reductase from rat intestine
β Scribed by Wieslaw J. Bochenek; John B. Rodgers
- Book ID
- 118309022
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 423 KB
- Volume
- 575
- Category
- Article
- ISSN
- 0005-2760
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π SIMILAR VOLUMES
Within the last few years considerable evidence has accumulated which indicates that changes in HMG-CoA reductase are due primarily, if not solely, to changes in enzyme quantity. These include the changes caused by insulin, glucagon, cholesterol, mevalonolactone, cholestyramine, compactin, cyclic mo
Addition of hemoglobin, methemoglobin, hemin or hematin in the assay mixture of rat liver 3-hydroxy-3-methylglutaryl CoA (HMGCoA) reductase inhibited the activity of the enzyme. The inhibition by hemin was rapid, without any apparent dependence on time of preincubation. At 20 microM hemin, a maximum