Male and female rats of Wistar strain were fed from the 6th week of life on during 10 and 30 days the diet containing 4.59,', or 26y; protein without or with addition of chlorfenvinphos (Chl) in concentrations of 5. 100 and 1000 ppm. The following was stated:
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In the case of optimal-protein diet (260,: protein): the inhibitory effect of Chl on the body weight gain at its highest concentration; the increased relative weight of liver, ovaries and adrenals dependent on the amount of the insecticide in the diet.
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In thc case of low-protein diet (4.5 ",) protein): the reduced rate of the body weight gain already at 5 ppni. pronounced at 100 ppm and strongly marked at I000 ppm of Chl; increase of the relative weight of testicles, adrenals and decrease of the relative weight of the spleen connccted with the increasing concentrations of Chl.
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In rats with the most decreased rate of the body weight gain (in case of Chl) an increase of the relative weight of the brain.
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Congestion of the heart, spleen and kidneys after 30 days on diets containing 100 and 1000 ppin of Chl. independent of the amount of protein in the diet.
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Eosinophilic infiltrations in the lungs of rats obtaining the 100 ppm-contaminated low-protein diet during 30 days.
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Focal degenerative changes in the cells of the exocrine pancreas and proliferation of lymphatic nodules 111 the spleen mainly in rats receiving the 1000 ppm-contaminated optimal-protein diet for 30 day5. After withdrawal of Chl from the diets changes caused by this insecticide 5howed reversal trends.
' The histological examination of the internal organs was done by Krystyna SZYMANSKA, M.D., from the