𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Dietary folate and colorectal cancer

✍ Scribed by Carlo La Vecchia; Eva Negri; Claudio Pelucchi; Silvia Franceschi

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
53 KB
Volume
102
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Folate may be inversely related to colorectal cancer risk, possibly in combination with low methionine and high alcohol consumption. We considered, therefore, the relation between folate and colorectal cancer in a multicentric case‐control study of 1,953 cases and 4,154 controls from Italy, i.e., a population with frequent regular alcohol drinking. In the overall data set, the odds ratio (OR) was 0.72 for the highest quintile of folate, and the continuous OR per 100 μg was 0.86. The inverse relation was similar in men and women and somewhat stronger for the rectum (OR = 0.59 for the highest quintile) compared to the colon (OR = 0.81). It was also somewhat stronger in the highest tertile of alcohol drinking (OR = 0.65), though trends were not heterogeneous across strata of alcohol, whereas no appreciable difference was observed across strata of methionine intake. Compared to subjects reporting low alcohol, high methionine and high folate intake, the OR was 1.83 for those reporting high alcohol, low methionine and low folate intake. The present findings support a favorable role of folate in colorectal carcinogenesis. © 2002 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Folate intake and colorectal cancer risk
Folate intake and colorectal cancer risk: A meta-analytical approach
✍ Miguel A. Sanjoaquin; Naomi Allen; Elisabeth Couto; Andrew W. Roddam; Timothy J. 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 94 KB

## Abstract Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta‐analysis of 7 cohort and 9 case‐control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption

Dietary calcium, vitamin D, VDR genotype
Dietary calcium, vitamin D, VDR genotypes and colorectal cancer
✍ Martha L. Slattery; Susan L. Neuhausen; Michael Hoffman; Bette Caan; Karen Curti 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 98 KB

## Abstract The vitamin D receptor (VDR) may importantly modulate risk of colorectal cancer either independently or in conjunction with calcium and vitamin D intake. We evaluate the association between calcium, vitamin D, dairy products, and __VDR__ polymorphisms in 2 case‐control studies of colon

Folate fortification, plasma folate, hom
Folate fortification, plasma folate, homocysteine and colorectal adenoma recurrence
✍ María Elena Martínez; Edward Giovannucci; Ruiyun Jiang; Susanne M. Henning; Eliz 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 99 KB

## Abstract In 1996, the US Food and Drug Administration mandated the fortification of grain products with folic acid, a nutrient that has been associated with lower risk of colorectal neoplasia. We assessed the relation of plasma folate and homocysteine and colorectal adenoma recurrence separately

Dietary fibres as “prebiotics”: Implicat
Dietary fibres as “prebiotics”: Implications for colorectal cancer
✍ Chiara C. Lim; Lynnette R. Ferguson; Gerald W. Tannock 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 402 KB

## Abstract A “prebiotic” is a nondigestible food ingredient whose beneficial effects on the host result from the selective stimulation of growth and/or activity of members of the bacterial community that inhabits the human bowel (the gut microbiota). Although much of the prebiotic literature focus

Dietary fatty acids, luminal modifiers,
Dietary fatty acids, luminal modifiers, and risk of colorectal cancer
✍ Ikuko Kato; Adhip P. Majumdar; Susan J. Land; Jill S. Barnholtz-Sloan; Richard K 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 162 KB 👁 1 views

## Abstract Inconsistent observations in epidemiologic studies on the association between total fat intake and colorectal cancer may be ascribed to opposing effects of individual fatty acids and the presence of other dietary constituents that modify luminal or systemic lipid exposure. We analyzed t

Is dietary fat, vitamin D, or folate ass
Is dietary fat, vitamin D, or folate associated with pancreatic cancer?
✍ G.V. Sanchez; S.J. Weinstein; R.Z. Stolzenberg-Solomon 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB

## Abstract Although potentially modifiable risk factors for pancreatic cancer include smoking, obesity, and diabetes, less is known about the extent to which diet affects cancer risk. Recent studies have demonstrated some consistency for dietary fat being associated with elevated pancreatic cancer