Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

✍ Scribed by Ho, L.

• Book ID: 120060300
• Publisher: The Federation of American Societies for Experimental Biology
• Year: 2004
• Tongue: English
• Weight: 126 KB
• Volume: 18
• Category: Article
• ISSN: 0892-6638
• DOI: 10.1096/fj.03-0978fje

✦ Synopsis

SPECIFIC AIMS

Insulin resistance, a proximal cause of Type II diabetes (a non-insulin-dependent form of diabetes mellitus (NIDDM)), is associated with an increased relative risk for Alzheimer's disease (AD). To clarify how NIDDM may influence Alzheimer's disease (AD) neuropathology, we explore the role of experimental NIDDM-like insulin resistance in the Tg2576 mouse model, which develops AD type neuropathology.