Diet high in oat β-glucan activates the gut-hypothalamic (PYY3–36-NPY) axis and increases satiety in diet-induced obesity in mice

✍ Scribed by Xu-Feng Huang; Yinghua Yu; Eleanor J. Beck; Tim South; Yulin Li; Marijka J. Batterham; Linda C. Tapsell; Jiezhong Chen

• Book ID: 102515827
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 101 KB
• Volume: 55
• Category: Article
• ISSN: 1613-4125
• DOI: 10.1002/mnfr.201100095

✦ Synopsis

Abstract

This study tested the effects of (1→3),(1→4) β‐D‐glucan from oats, on activation of the gut‐hypothalamic (PYY~3–36~‐NPY) axis, satiety, and weight loss in diet‐induced obesity (DIO) mice.

DIO mice were fed standard lab chow diets or varied doses of β‐glucan for 6 weeks. Energy intake, satiety, body weight changes and peptide Y‐Y~3‐36~ (PYY~3‐36~) were measured together with a satiety test and measurement of neuropeptide Y (NPY) mRNA expression in the hypothalamic arcuate nucleus (Arc). The average energy intake (‐13%, p<0.05) and body weight gain was lower with increasing β‐glucan over 6 wk with acute suppression of energy intake over 4 h. The highest β‐glucan diet significantly increased plasma PYY~3‐36~, with suppression of Arc NPY mRNA.