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Diepoxybutane induces caspase and p53-mediated apoptosis in human lymphoblasts

✍ Scribed by Sridevi Yadavilli; Perpetua M Muganda

Book ID
113923248
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
489 KB
Volume
195
Category
Article
ISSN
0041-008X

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## Abstract Diepoxybutane (DEB) is the most potent active metabolite of the environmental chemical 1,3‐butadiene (BD). BD is a known mutagen and human carcinogen and possesses multisystems organ toxicity. We previously reported the elevation of p53 in human TK6 lymphoblasts undergoing DEB‐induced a