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Diels—Alder/Thiol—Olefin Co-oxygenation Approach to Antimalarials Incorporating the 2,3-Dioxabicyclo[3.3.1]nonane Pharmacophore.

✍ Scribed by Paul M. O'Neill; Edite Verissimo; Stephen A. Ward; Jill Davies; Edward E. Korshin; Nuna Araujo; Matthew D. Pugh; M. Lurdes S. Cristiano; Paul A. Stocks; Mario D. Bachi


Book ID
101992580
Publisher
John Wiley and Sons
Year
2006
Weight
28 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract 7‐Oxanorbornene derivatives functionalized with alkyneappendages undergo intramolecular enyne metathesis reactions to give __cis__‐fused 2,6‐dioxabicyclo[4.3.0]nonane derivatives. These compounds have a diene functionality thatallows their reaction with dienophiles (__N__‐phenylmaleimid