✦ LIBER ✦

Dieldrin-induced changes in isoenzyme composition in the livers of CF-1 mice

✍ Scribed by Ben Van Ravenzwaay; Hilda J. M. Toussant; Rolf L. Schmitt

Publisher: John Wiley and Sons
Year: 1988
Tongue: French
Weight: 482 KB
Volume: 41
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910410223

No coin nor oath required. For personal study only.

✦ Synopsis

The isoenzyme composition of lactic dehydrogenase (LDH), pyruvate kinase (PK) and alanine-aminotransferase was determined in the livers of CF-I mice exposed to 0, 5 or 10 ppm dieldrin in the diet, over a period of 14 months. This study was carried out to evaluate whether the liver tumor promoter dieldrin advances the biological age of CF-I mouse liver. Oral dieldrin exposure induced a dose-dependent shift towards the fetal types of lactic dehydrogenase and pyruvate kinase, within 1.5 months of initiation of treatment. After the initial shift, no additional dieldrin-dependent changes were found in CF-I mouse liver throughout the experimental observation period. Thus, the initial shifts in isoenzyme composition of L D H and PK appear to reflect the adaptation of the liver to increased functional demands imposed by dieldrin treatment. The expression of the cytoplasmic A-alanine-aminotransferase isoenzyme decreased with age in untreated control mice. Dieldrin treatment enhanced this process in a dose-dependent manner. These data suggest that dieldrin treatment can accelerate age-dependent changes in gene expression.

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