✦ LIBER ✦
Die Struktur kollagenähnlicher Homo- und Heteropolytripeptide, 4. Polytripeptide durch repetitive Peptidsynthese und Verbrückung von Oligopeptiden
✍ Scribed by Roth, Werner ;Heppenheimer, Kurt ;Heidemann, Eckhart R.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1979
- Weight
- 603 KB
- Volume
- 180
- Category
- Article
- ISSN
- 0025-116X
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✦ Synopsis
Abstract
Collagen‐ like oligopeptides of defined chain length were synthesized via the following tripeptides which were combined stepwise: Boc‐Gly‐L‐Pro‐L‐Pro‐OH (1), Boc‐Gly‐L‐Pro‐L‐Lys‐OH (2), Boc‐L‐Ala‐Gly‐L‐Pro‐OH (4), Boc‐Gly‐L‐Pro‐L‐Leu‐OH (6), and Boc‐L‐Ala‐L‐Hyp(OBz)‐Gly‐OH (9). Two methods for covalent bridging of three oligopeptides of the same sequence were applied resulting in the formation of polypeptides of type 22 or 23.