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Die Struktur einer Vitamin-K2-Verbindung aus Tuberkelbazillen und die Synthese höherer Isoprenologe der Vitamin-K2-Reihe

✍ Scribed by H. Noll; R. Rüegg; U. Gloor; G. Ryser; O. Isler


Publisher
John Wiley and Sons
Year
1960
Tongue
German
Weight
326 KB
Volume
43
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

Vitamin K~2(x)~ m.p. 58–59º, isolated by NOLL from M. tuberculosis, proved to be 2‐methyl‐3‐solanesyl‐1,4‐naphthoquinone having a side‐chain of 45 C‐atoms. This vitamin K~2(45)~ was synthesized from menadiol and solanesol. The next higher isoprenologue, vitamin K~2(50)~ m.p. p. 62°, was obtained by lengthening solanesol by an isoprene unit followed by condensation with menadiol and oxidation.