Die spontane Spaltung von 3,3-Diäthyl-5-methylpiperidin-2,4-dion(Methyprylon) in die optischen Isomeren. Eine Rötgenstrukturanalyse eines isodimorphen Systems von Mischkristallen

✍ Scribed by Willi E. Oberhänsli

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: German
• Weight: 522 KB
• Volume: 65
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19820650325

✦ Synopsis

The Spontaneous Resolution of the 3,3‐Diethyl‐5‐methylpiperidine‐2,4‐dione (Methyprylon) into its Optical Isomers. An X‐Ray Structure Analysis of an Isodimoophous System of Mixed Crystals

Repeated recrystallizations from acetone of a racemic mixture of the title compound successively result in a spontaneous resolution into optical isomers [1]. In this process batches of mixed crystals of increased optical purity are formed [2]. This phenomena was investigated on a molecular basis using X‐ray diffraction methods. The mixed crystals belong to the space group __P__2~1~2~1~2~1~ and their diffraction patterns give no indication of major disorders. There is a linear relationship between the changes in unit cell parameters a and b and the optical rotation of the sample. The structures of the mixed crystals from four fractions belonging to two different crystalline modifications have been determined. The molecular shape is such that most of the atomic positions of the two enantiomers superimpose almost perfectly. Occupation factors determined for the asymmetric C‐ sites agree well with the optical activity of the crystals fraction.