Die cutan-allergische Reaktion auf 2,4-Dinitrochlorbenzol bei kindlichen Leuk�mien und soliden Tumoren
✍ Scribed by Schulte-Wissermann, H. ;Neidhardt, M. ;Oda, Y.
- Publisher
- Springer-Verlag
- Year
- 1973
- Weight
- 680 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0044-2917
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✦ Synopsis
The delayed type of hypersensitivity on the skin was studied after application of 2,4-dinitrochlorbenzol (DNCB) or tuberculin to 40 children who had either acute leukemia or solid tumors. Thirty-one patients were used as a control group. There was a significant difference in the results between the neoplasm group and the control group. It proved more difficult to sensitize the leukemia and tumor groups with DNCB. The negative reaction is thought to be caused primarily by irradiation therapy or by eytostatic agents. However, on remission of leukemia a higher amount of positive skin reactions was observed in spite of the cytostatie therapy. Children suffering from primary neurogenic tumors also showed significantly less positive reactions than those who had sarcoma. Therefore other factors must exist that influence the immunologic reaction. A plasma factor is to be discussed in this study.