Die Bootkonformation von cyclo-[L-Pro2-D-Pro]
✍ Scribed by Dr. Jan Willem Bats; Axel Friedrich; Prof. Dr. Hartmut Fuess; Prof. Dr. Horst Kessler; Werner Mästle; Prof. Dr. Manfred Rothe
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 255 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0044-8249
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Ulm, Federal Republic of Gennany ## Synopsis Combinations of L-and D-proline residues are useful compounds for finding new structures and properties of cyclic peptides. This is demonstrated with one striking example, the cyclic tetrapeptide ~(D-P~o-L-P~o-D-P~o-L-P~o). For this molecule composed o
The title compound represents the smallest member of cyclic proline peptides corresponding to the general formula c ( DDLL-Pro,), with a strictly D,D,L,L double-alternating sequence of the chiral amino acid residues. The cyclopeptides with n 2 2 could be synthesized from both DDLL-Pro4 ( 1 ) and DLL
## Abstract The crystal structure and conformation of the synthetic cyclic tetrapeptide, __cyclo__(L‐Pro‐Sar)~2~, was determined by x‐ray analysis. The peptide crystallizes in the orthorhombic space group __P__2~1~2~1~2~1~ with cell parameters __a__ = 9.277(1), __b__ = 12.884(1), and __c__ = 15.581