Didanosine, a new antiretroviral drug
β Scribed by Franssen, R. M. E. ;Meenhorst, P. L. ;Koks, C. H. W. ;Beijnen, J. H.
- Publisher
- Springer
- Year
- 1992
- Tongue
- Dutch
- Weight
- 910 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1573-739X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The "D drug" HIV reverse-transcriptase inhibitors zalcitabine, didanosine, and stavudine are relatively strong inhibitors of polymerase-gamma compared with the "non-D drugs" zidovudine, lamivudine, and abacavir. D drugs deplete mitochondrial DNA (mtDNA) in cultured hepatocytes. This mtDNA depletion
## Abstract Resistance to available antiretroviral (ARV) agents is of increasing concern, and development of novel agents that address this problem has been identified as a major public health priority. As ARV resistance becomes more prevalent with extended use of existing agents, individuals with
## Abstract DNA sequencing of a __pol__ gene fragment from drugβnaive injecting drug users samples obtained at two time points of the Brazilian AIDS epidemic (PreβHAART era: 1994 to early 1997, nβ=β27; postβHAART era: 1999β2001, nβ=β38) was undertaken to assess HIVβ1 antiretroviral drug resistance