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Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse

✍ Scribed by Mahua Mukhopadhyay; Svetlana Shtrom; Concepcion Rodriguez-Esteban; Lan Chen; Tohru Tsukui; Lauren Gomer; David W. Dorward; Andrei Glinka; Alexander Grinberg; Sing-Ping Huang; Christof Niehrs; Juan Carlos Izpisúa Belmonte; Heiner Westphal


Book ID
117795058
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
568 KB
Volume
1
Category
Article
ISSN
1534-5807

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Evidence in animal models indicates that signaling networks functioning in the developing pharyngeal arches regulate stereotyped processes critical for proper development of the aortic arch and cardiac outflow tract. Here, we describe the phenotype of mice lacking fibroblast growth factor 15 (Fgf15)