## Abstract ## Background Indoleamine 2,3‐dioxygenase (IDO) is an enzyme involved in the catabolism of tryptophan and has been shown to prevent rejection of the fetus during pregnancy by inhibiting alloreactive T cells. ## Methods In this study we investigated dendritic cells (DCs) that are tran
✦ LIBER ✦
Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells
✍ Scribed by Toshiaki Hara; Fumiyuki Yamakura; Osamu Takikawa; Rie Hiramatsu; Tsutomu Kawabe; Ken-ichi Isobe; Fumihiko Nagase
- Book ID
- 113717482
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 484 KB
- Volume
- 332
- Category
- Article
- ISSN
- 0022-1759
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## Abstract Following CD80/86 (B7) and TLR9 ligation, small subsets of splenic dendritic cells expressing CD19 (CD19^+^ DC) acquire potent T cell regulatory functions due to induced expression of the intracellular enzyme indoleamine 2,3‐dioxygenase (IDO), which catabolizes tryptophan. In CD19^+^ DC
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