## Abstract 3‐Hydroxypropionitrile was subjected to a base‐catalyzed exchange reaction in D~2~O which provided 2,2‐dideuterio‐3‐deuteroxypropionitrile (DOCH~2~CD~2~CN) in 70% yield. Reduction of the nitrile with LiAlD~4~ gave 3‐amino‐2,2,3,3‐tetradeuteriopropan‐1‐o1 (HOCH~2~CD~2~CD~2~NH~2~) in a cr
Diastereospecific chemical synthesis of ribonucleosides-3′,4′,5′,5″ -d4
✍ Scribed by Anna Trifonova; András Földesi; Zoltán Dinya; Jyoti Chattopadhyaya
- Book ID
- 104209306
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 1011 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
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## Abstract Starting from substrates (I), the title skeleton (VI) is prepared via tricyclic precursors of type (II).
## Abstract Synthesis of L‐[2,3,4,5‐D~4~]ornithine in which all of the diastereotopic hydrogens were stereoselectively labeled with deuterium was investigated. The chirally deuterated 3‐aminopropanal derivative, a key intermediate in this synthesis, was prepared by a catalytic deuteration of an uns
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