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Diastereoselectivity in the alkylations of bicyclic piperidinones

✍ Scribed by Catherine E. Mills (née Davis); Thomas D. Heightman; Stephen A. Hermitage; Mark G. Moloney; Gordon A. Woods

Book ID
104258588
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
260 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of substituted [4.3.0] bicyclic iactams derived from 6-oxo-2-hydroxymethylpip~ridine is described. The enolate dm'ived f~om these systems can be alkylated with a range of reactive electrophiles; the diastereoselectivity which can be achieved depends on the substitution pattern of the oxazofidine ring system and the nature of the alkylating reagent, and can vary from 1:1 to as much as 10:1.

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