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Diastereoselective Synthesis of β2-Amino Acids

✍ Scribed by Rachel Ponsinet; Gérard Chassaing; Jacqueline Vaissermann; Solange Lavielle

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
423 KB
Volume
2000
Category
Article
ISSN
1434-193X

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✦ Synopsis

As part of an ongoing project concerning the synthesis of deprotection and Boc-protection yielded the expected β 2amino acids. X-ray analysis of the alkylation product nonnatural amino acids, we have now developed a general strategy for the preparation of β 2 -amino acids (or 2-established that (Ϫ)-sultam yielded (R)-β 2 -amino acids, conversely (+)-sultam yielded the enantiomer. The topicity of aminocarboxylic acid derivatives). Our procedure involves the synthesis of the sultam β-alaninate precursor 5 whose this alkylation is in agreement with the alkylation of OppolzerЈs precursor for the synthesis of α-amino acids and alkylation led with high yields and excellent diastereoselectivity to the precursor of β 2 -homophenyl-opposite to that observed for gem-dialkylation. alanine, β 2 -homoalanine, and β 2 -homoleucine. Subsequent

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