𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Diastereoselective Synthesis of α-Methyl and α-Hydroxy-β-Amino Acids via 4-Substituted-1,3-Oxazinan-6-ones

✍ Scribed by Sleebs, Brad E.; Hughes, Andrew B.


Book ID
124159800
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
232 KB
Volume
72
Category
Article
ISSN
0022-3263

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Concise enantio- and diastereoselective
✍ Rolf Roers; Gregory L Verdine 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 66 KB

Reported here is an efficient procedure for enantio-and diastereoselective synthesis of pure b-amino acids that display a tert-hydroxyl functionality in the a-position. Key steps include a catalytic asymmetric aldol reaction and a modified Curtius rearrangement to form oxazolidinone intermediates, w

Effective Methods for the Synthesis of N
✍ Andrew B. Hughes; Brad E. Sleebs 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 278 KB

N-Methyl b-amino acids are generally required for application in the synthesis of potentially bioactive modified peptides and other oligomers. Previous work highlighted the reductive cleavage of 1,3-oxazolidin-5-ones to synthesise N-methyl a-amino acids. Starting from a-amino acids, two approaches w