Diastereoselective Synthesis of α-Methyl and α-Hydroxy-β-Amino Acids via 4-Substituted-1,3-Oxazinan-6-ones
✍ Scribed by Sleebs, Brad E.; Hughes, Andrew B.
- Book ID
- 124159800
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 232 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
Reported here is an efficient procedure for enantio-and diastereoselective synthesis of pure b-amino acids that display a tert-hydroxyl functionality in the a-position. Key steps include a catalytic asymmetric aldol reaction and a modified Curtius rearrangement to form oxazolidinone intermediates, w
N-Methyl b-amino acids are generally required for application in the synthesis of potentially bioactive modified peptides and other oligomers. Previous work highlighted the reductive cleavage of 1,3-oxazolidin-5-ones to synthesise N-methyl a-amino acids. Starting from a-amino acids, two approaches w