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Diastereoselective Synthesis of N,N -Dibenzyl-Protected Aminoalkyl Hydroxyethylamines: Key Building Blocks for Hydroxyethylamine-Based BACE1 Inhibitor

✍ Scribed by Wu, Jie; Gao, Shanyun; Liao, Guochao; Lin, Hansen; Nie, Aihua


Book ID
120407127
Publisher
Taylor and Francis Group
Year
2012
Tongue
English
Weight
288 KB
Volume
42
Category
Article
ISSN
0039-7911

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✍ M. Ángeles López-García; Inés Maya; José G. Fernández-Bolaños; Giovanna Bosica; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 262 KB 👁 1 views

## Abstract A highly efficient conversion of β‐nitrostyrenes into a new kind of functionalized __N__‐alkoxy‐2‐hydroxypiperidine in two steps was developed, giving excellent yields and diastereoselectivity. The prepared compounds are the first examples of __N__‐alkoxy‐2‐hydroxypiperidines. The synth