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Diastereoselective Synthesis of Fused Lactone-Pyrrolidinones; Application to a Formal Synthesis of (−)-Salinosporamide A

✍ Scribed by Logan, Angus W. J.; Sprague, Simon J.; Foster, Robert W.; Marx, Léo B.; Garzya, Vincenzo; Hallside, Michal S.; Thompson, Amber L.; Burton, Jonathan W.


Book ID
127021962
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
543 KB
Volume
16
Category
Article
ISSN
1523-7060

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A novel diastereoselective synthesis of
✍ Kapa Prasad; Oljan Repič 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 186 KB

A new synthesis of racemic $-hydroxy-&lactone 10 with requisite relative stereochemistry as in compactin (la) is described utilizing cis-cyclohexane-1,3,5-trio1 (2) as the starting material. Compactin' (la) and mevinolin\* -(lb) have attracted a great deal of interest from synthetic organic chemists