Diastereoselective synthesis of chloro- and fluoro-aniline containing phosphonate esters in a three-component condensation

✍ Scribed by Malek Taher Maghsoodlou; Nourallah Hazeri; Sayyed Mostafa Habibi-Khorassani; Ghasem Marandi; Lotfali Saghatforoush; Danial Saravani; Niloufar Akbarzadeh Torbati; Faramarz Rostami-Charati; Khatereh Khandan-Barani; Brian W. Skelton; Mohamed Makha

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 276 KB
• Volume: 21
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.20600

✦ Synopsis

Abstract

New phosphonate ester derivatives were obtained by in situ stereo‐specific reaction between triphenyl phosphite and dialkyl acetylenedicarboxylates in the presence of a series of halogenated anilines. Spectroscopic data and X‐ray crystallography analysis are in agreement with the gauche arrangement for the two vicinal protons in the structures. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:222–227, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20600