## 2S,4R~R)-2-Met~~~-~~~l-3-(4-merhylbe~enesu~onyl)-5-phenyl-l 3-oxazolidine (2~) ad& trimethylsilyl I-cycloalkenyl ethers under L.ewis acid catalysis with complete induced and high simple &astereoselectivi@ to yield homochiral oxazolidine-m&ed 2-formylalknnones. Key words: 2-
Diastereoselective Synthesis of 2-Aminoalkyl-3-sulfonyl-1,3-oxazolidines on Solid Support
โ Scribed by Conde-Frieboes, Kilian; Schjeltved, Rie K.; Breinholt, Jens
- Book ID
- 120442481
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 150 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
1,3-Oxazolidines 9 were synthesized by using a solid support. Regioselective ring opening of resin-bound epoxy ether 3 with ammonium chloride followed by nucleophilic substitution with sodium azide gave azido alcohol 7. Reduction of 7 provided 1-amino-2-alkanol 6, which was treated with various alde
A versatile method for the solid phase synthesis of oxazolidin-2-ones is described. A resin bound phenolic group was treated with (ยฑ)-epichlorohydrin followed by opening of the epoxide ring with sodium azide. The resulting 1-azido-3-aryloxypropan-2-ol was treated with p-nitrophenylchloroformate and