Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and α-Amino Esters
✍ Scribed by Greg Hughes; Paul N. Devine; John R. Naber; Paul D. O'Shea; Bruce S. Foster; Daniel J. McKay; R. P. Volante
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 151 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0044-8249
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Diastereoselective Synthesis of N-(α-Aryl-α-haloacetyl) Amino Acid Esters by Acylation Using 3-Aryl-2,2-dicyanooxiranes. -α-Arylα-bromo ketenes are generated in situ starting from epoxides (I) by treatment with Li 2 NiBr 4 , followed by the addition of Et 3 N at -78 • C. Trapping of these intermedi