Diastereoselective methylation of ls-α-phenylethyl-Δ9,10-octahydroquinol-4-one
✍ Scribed by G. V. Grishina; V. M. Potapov; T. V. Tyrtysh
- Book ID
- 112356345
- Publisher
- Springer US
- Year
- 1984
- Tongue
- English
- Weight
- 372 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0009-3122
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
CH,(18) + 14-CH3; 2.07, s CH,( 4) (CDCI,);not yet crystalli~ed]~). Finally, 8 was converted by catalytic hydrogenation [5%-Pd/C in ethanol/triethylamine; + 11 and cyclisation [HCl in acetic acid] into 3-oxo-17~-acetoxy-14a-methyl-A4-8a,9B,lOa,13a-estrene (12) [m.p. 86-88'; -[ U ] D = + 1' (CHC1,).
HE ANDROGENIC steroids most effective in T the treatment of metastatic breast cancer have all been potent androgens. T o date, the less potent androgens have been less effective.3~4 Hence, when an androgen more potent than testosterone or methyltestosterone became available it was thought important