The first asymmetric synthesis of (2R, 3R)-3-amino-l-benzyl-2-methylpyrrolidine, the parent diamine of antipsychotic agent, emonapride, from (S)-malic acid was achieved via a highly diastereroselective reductive alkylation.
Diastereoselective Conjugate Reduction with Samarium Diiodide: Asymmetric Synthesis of Methyl (2S,3R)-N-Acetyl-2-amino-2,3-dideuterio-3-phenylpropionate.
β Scribed by Stephen G. Davies; Humberto Rodiguez-Solla; Juan A. Tamayo; A. Christopher Garner; Andrew D. Smith
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 25 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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3-Amino-2-hydroxydecanoic acid (AHDA) is a novel amino acid which has been suggested as the Nterminal component of the recently isolated angiotensin-converting "enzyme inhibitor microginin. The naturally occurring amino acid was found to possess syn relative stereochemistry and (2S,3R) absolute ster
The authors regret that on page 271 the second author name was spelt incorrectly and should read as ''Shi Li Wang''. ## The value for [h] D of compound 6 on page 271 is also incorrect and should read as follows: [h] D 20 -83.9 (c 1.1 in CHCl 3 ).