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Diastereoselective arylation of enantiopure 3-bromopiperidin-2-one derived from (R)-(−)-2-phenylglycinol with organocuprate reagents

✍ Scribed by Oscar Romero; Alejandro Castro; Joel L. Terán; Dino Gnecco; María L. Orea; Ángel Mendoza; Marcos Flores; Luis F. Roa; Jorge R. Juárez


Book ID
113929929
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
856 KB
Volume
52
Category
Article
ISSN
0040-4039

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A Simple Stereoselective Synthesis of En
✍ José M. Andrés; Ignacio Herráiz-Sierra; Rafael Pedrosa; Alfonso Pérez-Encabo 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 319 KB 👁 2 views

Chiral, nonracemic 2-substituted pyrrolidines and piperidines were prepared in high ee and moderate to good chemical yields in three steps from (R)-phenylglycinol and γ-or δchloroketones. The key step of the synthesis was the stereo-