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Diastereoselective Approach to Substituted Oxazolidinones from Morita–Baylis–Hillman Adducts

✍ Scribed by Rezende, Patrícia; Paioti, Paulo H. S.; Coelho, Fernando


Book ID
127320252
Publisher
Taylor and Francis Group
Year
2010
Tongue
English
Weight
582 KB
Volume
41
Category
Article
ISSN
0039-7911

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We disclose herein a facile and straightforward method to access 3,4-substituted tetrahydro-1,8-naphthyridines from Morita-Baylis-Hillman. The strategy is based on a tandem sequence involving a Michael addition reaction followed by an intramolecular S N Ar reaction on a silylated-Morita-Baylis-Hillm