## Abstract Lithium and magnesium enolates of cyclohexanone undergo palladiumโcatalyzed allylic alkylations under mild conditions. Diastereoselectivity and enantioselectivity are observed when the diphenylโ and dimethylโsubstituted allylic substrates **1a** and **1b** are reacted with cyclohexanone
Diastereoselective and Enantioselective Palladium-Catalyzed Allylic Substitution with Nonstabilized Ketone Enolates
โ Scribed by Manfred Braun; Frank Laicher; Thorsten Meier
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 121 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0044-8249
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๐ SIMILAR VOLUMES
## Abstract Palladiumโcatalyzed asymmetric allylic alkylation of nonstabilized ketone enolates to generate quaternary centers has been achieved in excellent yield and enantioselectivity. Optimized conditions consist of performing the reaction in the presence of two equivalents of LDA as base, one e
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