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Diastereoselective and Enantioselective Palladium-Catalyzed Allylic Substitution with Nonstabilized Ketone Enolates

โœ Scribed by Manfred Braun; Frank Laicher; Thorsten Meier


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
121 KB
Volume
39
Category
Article
ISSN
0044-8249

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๐Ÿ“œ SIMILAR VOLUMES


Palladium-Catalyzed Diastereoselective a
โœ Manfred Braun; Thorsten Meier; Frank Laicher; Panos Meletis; Mesut Fidan ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 297 KB ๐Ÿ‘ 2 views

## Abstract Lithium and magnesium enolates of cyclohexanone undergo palladiumโ€catalyzed allylic alkylations under mild conditions. Diastereoselectivity and enantioselectivity are observed when the diphenylโ€ and dimethylโ€substituted allylic substrates **1a** and **1b** are reacted with cyclohexanone

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## Abstract Palladiumโ€catalyzed asymmetric allylic alkylation of nonstabilized ketone enolates to generate quaternary centers has been achieved in excellent yield and enantioselectivity. Optimized conditions consist of performing the reaction in the presence of two equivalents of LDA as base, one e

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