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Diastereoselective Alkylation of Tricyclic Lactim Ethers

✍ Scribed by André Hätzelt; Sabine Laschat; Peter G. Jones; Jörg Grunenberg

Book ID
101352848
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
167 KB
Volume
2002
Category
Article
ISSN
1434-193X

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📜 SIMILAR VOLUMES

Diastereoselective Alkylation of a Proli
Diastereoselective Alkylation of a Proline-Derived Bicyclic Lactim Ether
✍ Daniela Hendea; Sabine Laschat; Angelika Baro; Wolfgang Frey 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 217 KB

Dedicated to Professor Dieter Hoppe on the occasion of his 65th birthday N-Boc-protected L-proline (6) was converted into the bicyclic lactim ether (8aS)-6,7,8,8a-tetrahydro-1-methoxypyrrolo[1,2-a]pyrazin-4(3H)-one (5) in four steps (Scheme 1). Deprotonation with LDA or LHMDS and subsequent alkylati