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Diastereoselective Aldol Additions to α-Amino-β-silyloxy Aldehydes. Divergent Synthesis of Aminodiols.

✍ Scribed by Per Restorp; Peter Somfai


Publisher
John Wiley and Sons
Year
2005
Weight
30 KB
Volume
36
Category
Article
ISSN
0931-7597

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Three-Center Diastereoselective Aldol Ad
✍ Dr. Johann Mulzer; Alexander Chucholowski 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB

The a-hydroxyglycine 1 -readily accessible from glyoxylic acid hydrate and benzyl ~arbaminate[~I---was converted into the ethyl ether 2. Successive reaction with PCI3 and triethyl phosphite led to ethyl 2-benzyloxycarbonylamino-2-diethyloxyphosphorylacetate 3 (yield 80%). N-Acyl-2-(diethyloxyphospho