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Diastereofacial control in the Lewis acid catalyzed cyclocondensation reaction of aldehydes with activated dienes: a synthesis of the Mus musculus pheromone

✍ Scribed by Danishefsky, Samuel J.; Pearson, William H.; Harvey, Daniel F.


Book ID
126117874
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
263 KB
Volume
106
Category
Article
ISSN
0002-7863

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Scandium triflate (Sc(OTf)3)-catalyzed aldol reactions of silyl enol ethers with aldehydes were successfully carried out in micellar systems. While the reactions proceeded sluggishly in water, remarkable enhancement of the reactivity was observed in the presence of a small amount of a surfactant. In